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Cerebral atherosclerosis

DOID EFO MESH SNOMED PheWeb

I9_CEREBATHER

cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I67.2
Hospital discharge: ICD-9 4370
Hospital discharge: ICD-8 437
Cause of death: ICD-10 I67.2
Cause of death: ICD-9 4370
Cause of death: ICD-8 437

2 out of 7 registries used, show all original rules.

329

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Check minimum number of events None

329

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Include endpoints None

329

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Remove individuals based on genotype QC

322

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I9_CEREBATHER

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 I67
Name in latin Atherosclerosis cerebralis

Summary Statistics

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Key figures

All Female Male
Number of individuals 322 109 213
Unadjusted prevalence (%) 0.09 0.05 0.13
Mean age at first event (years) 70.31 69.88 70.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CEREBATHER – Cerebral atherosclerosis
GWS hits:

Survival analyses between endpoints

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Plot

before Cerebral atherosclerosis
after Cerebral atherosclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Cerebral atherosclerosis

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Endpoint not on priority list, no data to show.