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Angina pectoris

DOID EFO MESH SNOMED PheWeb

I9_ANGINA

Prinzmetal's angina: a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I20
Hospital discharge: ICD-9 413|411[0-1]
Hospital discharge: ICD-8 413
Cause of death: ICD-10 I20
Cause of death: ICD-9 413|411[0-1]
Cause of death: ICD-8 413

2 out of 7 registries used, show all original rules.

35565

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Check minimum number of events None

35565

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Include endpoints None

35565

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Remove individuals based on genotype QC

34456

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I9_ANGINA

Control definitions

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I20-I25
Name in latin Angina pectoris

Summary Statistics

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Key figures

All Female Male
Number of individuals 34456 11507 22949
Unadjusted prevalence (%) 9.14 5.46 13.80
Mean age at first event (years) 63.18 64.19 62.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.93 [1.74, 2.15] 7.6e-35 10141
15 years 0.01 1.44 [1.32, 1.58] 3.2e-16 5014
5 years 0.00 2.10 [1.95, 2.27] 1.3e-80 2252
1 year 0.00 4.99 [4.48, 5.56] <1e-100 1021

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ANGINA – Angina pectoris
GWS hits: 63

Survival analyses between endpoints

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Plot

before Angina pectoris
after Angina pectoris

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Angina pectoris

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Endpoint not on priority list, no data to show.