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Ménière disease

DOID EFO MESH SNOMED PheWeb

H8_MENIERE

endolymphatic hydrops: An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H81.0
Hospital discharge: ICD-9 3860
Hospital discharge: ICD-8 38599
Cause of death: ICD-10 H81.0
Cause of death: ICD-9 3860
Cause of death: ICD-8 38599

2 out of 7 registries used, show all original rules.

2828

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Check minimum number of events None

2828

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Include endpoints None

2828

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Remove individuals based on genotype QC

2746

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H8_MENIERE

Control definitions

Control exclude H8_INNER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H81
Name in latin Morbus Ménière

Summary Statistics

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Key figures

All Female Male
Number of individuals 2746 1782 964
Unadjusted prevalence (%) 0.73 0.85 0.58
Mean age at first event (years) 55.39 54.31 57.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.55 [1.03, 2.33] 3.7e-2 231
15 years 0.01 1.13 [0.81, 1.59] 4.7e-1 110
5 years 0.00 1.64 [1.12, 2.39] 1.0e-2 43
1 year 0.00 3.10 [1.79, 5.40] 5.9e-5 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_MENIERE – Ménière disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Ménière disease
after Ménière disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ménière disease

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Endpoint not on priority list, no data to show.