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Sensorineural hearing loss

DOID EFO MESH SNOMED PheWeb

H8_HL_SEN_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891

2 out of 7 registries used, show all original rules.

33471

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Check minimum number of events None

33471

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Include endpoints None

33471

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Remove individuals based on genotype QC

32487

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H8_HL_SEN_NAS

Control definitions

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 32487 15234 17253
Unadjusted prevalence (%) 8.62 7.23 10.38
Mean age at first event (years) 64.59 62.68 66.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.70 [1.45, 2.00] 6.3e-11 4347
15 years 0.01 1.07 [0.95, 1.22] 2.7e-1 2164
5 years 0.00 1.88 [1.70, 2.08] 4.8e-34 1440
1 year 0.00 2.53 [2.20, 2.91] 7.8e-38 376

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 28

Survival analyses between endpoints

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Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss

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Endpoint not on priority list, no data to show.