Sensorineural hearing loss

H8_HL_SEN_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5
Hospital discharge: ICD-9 3891
Cause of death: ICD-10 H90.3, H90.4, H90.5
Cause of death: ICD-9 3891

2 out of 7 registries used, show all original rules.

33471

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Check minimum number of events None

33471

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Include endpoints None

33471

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Remove individuals based on genotype QC

32487

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H8_HL_SEN_NAS

Control definitions

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 32487 15234 17253
Unadjusted prevalence (%) 8.62 7.23 10.38
Mean age at first event (years) 64.59 62.68 66.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.70 [1.45, 2.00] 6.3e-11 4347
15 years 0.01 1.07 [0.95, 1.22] 2.7e-1 2164
5 years 0.00 1.88 [1.70, 2.08] 4.8e-34 1440
1 year 0.00 2.53 [2.20, 2.91] 7.8e-38 376

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 28

Survival analyses between endpoints

Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sensorineural hearing loss

Endpoint not on priority list, no data to show.