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Other specified/unspecified hearing loss

DOID EFO MESH SNOMED PheWeb

H8_HL_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H91.8, H91.9
Hospital discharge: ICD-9 389[8-9]
Hospital discharge: ICD-8 389
Cause of death: ICD-10 H91.8, H91.9
Cause of death: ICD-9 389[8-9]
Cause of death: ICD-8 389

2 out of 7 registries used, show all original rules.

2181

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Check minimum number of events None

2181

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Include endpoints None

2181

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Remove individuals based on genotype QC

2105

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H8_HL_NAS

Control definitions

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2105 1013 1092
Unadjusted prevalence (%) 0.56 0.48 0.66
Mean age at first event (years) 60.14 55.77 64.20

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.73 [1.95, 3.83] 5.3e-9 325
15 years 0.01 1.18 [0.82, 1.68] 3.7e-1 121
5 years 0.00 2.67 [1.81, 3.94] 6.9e-7 134
1 year 0.00 4.67 [3.05, 7.14] 1.3e-12 48

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_NAS – Other specified/unspecified hearing loss
GWS hits:

Survival analyses between endpoints

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Plot

before Other specified/unspecified hearing loss
after Other specified/unspecified hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other specified/unspecified hearing loss

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Endpoint not on priority list, no data to show.