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Mixed conductive and sensorineural hearing loss

DOID EFO MESH SNOMED PheWeb

H8_HL_MIX_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H90.6, H90.7, H90.8
Hospital discharge: ICD-9 3892
Cause of death: ICD-10 H90.6, H90.7, H90.8
Cause of death: ICD-9 3892

2 out of 7 registries used, show all original rules.

3729

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Check minimum number of events None

3729

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Include endpoints None

3729

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Remove individuals based on genotype QC

3581

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H8_HL_MIX_NAS

Control definitions

Control exclude H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 3581 1889 1692
Unadjusted prevalence (%) 0.95 0.90 1.02
Mean age at first event (years) 59.89 57.66 62.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.50 [0.80, 2.82] 2.0e-1 431
15 years 0.01 1.24 [0.80, 1.91] 3.3e-1 243
5 years 0.00 1.72 [1.23, 2.39] 1.3e-3 107
1 year 0.00 2.45 [1.58, 3.80] 6.1e-5 29

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_HL_MIX_NAS – Mixed conductive and sensorineural hearing loss
GWS hits:

Survival analyses between endpoints

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Plot

before Mixed conductive and sensorineural hearing loss
after Mixed conductive and sensorineural hearing loss

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Mixed conductive and sensorineural hearing loss

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Endpoint not on priority list, no data to show.