Retrobulbar neuritis in diseases classified elsewhere

H7_RETROBULBNEURINOTH

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H48.1*, H48.1*A39.8, H48.1*A52.1, H48.1*A69.2, H48.1*G35
Cause of death: ICD-10 H48.1*, H48.1*A39.8, H48.1*A52.1, H48.1*A69.2, H48.1*G35

2 out of 7 registries used, show all original rules.

101

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Check minimum number of events None

101

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Include endpoints None

101

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Remove individuals based on genotype QC

95

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H7_RETROBULBNEURINOTH

Control definitions

Control exclude H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 95 74 21
Unadjusted prevalence (%) 0.03 0.04 0.01
Mean age at first event (years) 42.84 41.76 46.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_RETROBULBNEURINOTH – Retrobulbar neuritis in diseases classified elsewhere
GWS hits:

Survival analyses between endpoints

Not a core endpoint, no data to show.

Drugs most likely to be purchased after Retrobulbar neuritis in diseases classified elsewhere

Endpoint not on priority list, no data to show.