≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Primary open-angle glaucoma, strict

DOID EFO MESH SNOMED PheWeb

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H40.1
Hospital discharge: ICD-9 3651[A|C|E|X]
Hospital discharge: ICD-8 37510
Hospital discharge: excluded ICD-10 H40.10, H40.12
Cause of death: ICD-10 H40.1
Cause of death: ICD-9 3651[A|C|E|X]
Cause of death: ICD-8 37510
Cause of death: excluded ICD-10 H40.10, H40.12

2 out of 7 registries used, show all original rules.

7998

diagram downward connector

Check minimum number of events None

7998

diagram downward connector

Include endpoints None

7998

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

7756

diagram downward connector
H7_GLAUCOMA_POAG

Control definitions

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H40
Name in latin Glaucoma simplex primarium

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 7756 4228 3528
Unadjusted prevalence (%) 2.06 2.01 2.12
Mean age at first event (years) 67.88 67.58 68.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.41 [1.11, 1.79] 4.5e-3 1193
15 years 0.01 0.97 [0.79, 1.19] 7.9e-1 615
5 years 0.00 1.46 [1.22, 1.74] 2.4e-5 325
1 year 0.00 1.93 [1.49, 2.49] 7.3e-7 81

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict
GWS hits: 38

Survival analyses between endpoints

↥

Plot

before Primary open-angle glaucoma, strict
after Primary open-angle glaucoma, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Primary open-angle glaucoma, strict

↥

Endpoint not on priority list, no data to show.