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Use of antiglaucoma preparations and miotics

DOID EFO MESH SNOMED PheWeb

H7_GLAUCOMAMEDICATION

glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Medicine purchases: ATC S01EA

1 out of 7 registries used, show all original rules.

2440

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Check minimum number of events

Min. number of events 3

2440

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Include endpoints None

2440

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Remove individuals based on genotype QC

2349

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H7_GLAUCOMAMEDICATION

Control definitions

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2349 1260 1089
Unadjusted prevalence (%) 0.62 0.60 0.65
Mean age at first event (years) 65.31 64.61 66.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.57 [1.19, 2.07] 1.6e-3 556
15 years 0.01 1.14 [0.91, 1.43] 2.4e-1 312
5 years 0.00 1.70 [1.37, 2.10] 1.3e-6 151
1 year 0.00 0.91 [0.53, 1.55] 7.3e-1 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_GLAUCOMAMEDICATION – Use of antiglaucoma preparations and miotics
GWS hits: 5

Survival analyses between endpoints

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Plot

before Use of antiglaucoma preparations and miotics
after Use of antiglaucoma preparations and miotics

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Use of antiglaucoma preparations and miotics

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Endpoint not on priority list, no data to show.