Sleep apnoea

G6_SLEEPAPNO

sleep apnea: A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G47.3
Hospital discharge: ICD-9 3472
Cause of death: ICD-10 G47.3
Cause of death: ICD-9 3472

2 out of 7 registries used, show all original rules.

40108

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Check minimum number of events None

40108

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Include endpoints None

40108

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Remove individuals based on genotype QC

38998

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G6_SLEEPAPNO

Control definitions

Control exclude G6_NARCOCATA, G6_SLEEPDISOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G47
Name in latin Apnoea intrasomnalis

Summary Statistics

Key figures

All Female Male
Number of individuals 38998 15635 23363
Unadjusted prevalence (%) 10.34 7.42 14.05
Mean age at first event (years) 56.10 56.36 55.92

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.41 [1.14, 1.74] 1.3e-3 2070
15 years 0.01 1.00 [0.85, 1.18] 9.8e-1 914
5 years 0.00 2.11 [1.83, 2.44] 5.0e-24 556
1 year 0.00 3.83 [3.16, 4.64] 5.0e-43 188

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_SLEEPAPNO – Sleep apnoea
GWS hits: 23

Survival analyses between endpoints

Plot

before Sleep apnoea
after Sleep apnoea

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