Inflammatory diseases of the central nervous system

DOID EFO MESH SNOMED PheWeb

G6_NEUINFL

encephalomyelitis: Inflammation of the brain and the spinal cord.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G00-G09

Cause of death: ICD-10 G00-G09

2 out of 7 registries used, show all original rules.

1699

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Check minimum number of events None

1699

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Include endpoints

G6_ADEM

G6_CNSABSC

G6_CNSPHLEB

2521

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Remove individuals based on genotype QC

2433

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G6_NEUINFL

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	G6_NEUINFL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	G6_MENINGBACT\|G6_MENINGVIR\|G6_MENINGOTH\|G6_ADEM\|G6_ENCEPHBACT\|G6_ENCEPHOTH\|G6_CNSABSC\|G6_CNSPHLEB\|G6_NEUROINFSEQ
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G0
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G0
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Inflammatory diseases of the central nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2433	1314	1119
Unadjusted prevalence (%)	0.65	0.62	0.67
Mean age at first event (years)	41.08	38.95	43.58

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.17 [1.08, 4.33]	2.9e-2	303
15 years	0.01	1.03 [0.60, 1.79]	9.1e-1	82
5 years	0.00	3.47 [2.32, 5.19]	1.4e-9	81
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_NEUINFL – Inflammatory diseases of the central nervous system
GWS hits:

Survival analyses between endpoints

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Plot

before Inflammatory diseases of the central nervous system
after Inflammatory diseases of the central nervous system

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Table

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Drugs most likely to be purchased after Inflammatory diseases of the central nervous system

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Endpoint not on priority list, no data to show.