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MS-disease / Multiple Sclerosis

DOID EFO MESH SNOMED PheWeb

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G35
Hospital discharge: ICD-9 340
Hospital discharge: ICD-8 34099
Cause of death: ICD-10 G35
Cause of death: ICD-9 340
Cause of death: ICD-8 34099
KELA reimbursements: KELA codes 109

3 out of 7 registries used, show all original rules.

2299

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Check minimum number of events None

2299

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Include endpoints None

2299

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Remove individuals based on genotype QC

2182

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G6_MS

Control definitions

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G35-G37
Name in latin Sclerosis multiplex

Summary Statistics

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Key figures

All Female Male
Number of individuals 2182 1648 534
Unadjusted prevalence (%) 0.58 0.78 0.32
Mean age at first event (years) 39.45 38.45 42.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.17 [0.55, 2.50] 6.8e-1 94
15 years 0.01 0.90 [0.46, 1.76] 7.7e-1 42
5 years 0.00 1.99 [1.07, 3.70] 3.1e-2 22
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 5

Survival analyses between endpoints

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Plot

before MS-disease / Multiple Sclerosis
after MS-disease / Multiple Sclerosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after MS-disease / Multiple Sclerosis

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