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Hereditary motor and sensory neuropathy

DOID EFO MESH PheWeb

G6_HEREMOSEN

charcot-marie-tooth disease, axonal, type 2t: ['Charcot-Marie-Tooth disease type 2T (CMT2T) is a slowly progressive autosomal recessive sensorimotor peripheral neuropathy with onset in middle age (Higuchi et al., 2016).']

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G60.0
Hospital discharge: ICD-9 3560
Hospital discharge: ICD-8 33000
Cause of death: ICD-10 G60.0
Cause of death: ICD-9 3560
Cause of death: ICD-8 33000

2 out of 7 registries used, show all original rules.

227

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Check minimum number of events None

227

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Include endpoints None

227

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Remove individuals based on genotype QC

218

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G6_HEREMOSEN

Control definitions

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G60
Name in latin Neuropathia motoria et sensoria hereditaria

Summary Statistics

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Key figures

All Female Male
Number of individuals 218 117 101
Unadjusted prevalence (%) 0.06 0.06 0.06
Mean age at first event (years) 46.21 44.69 47.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_HEREMOSEN – Hereditary motor and sensory neuropathy
GWS hits: 6

Survival analyses between endpoints

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Plot

before Hereditary motor and sensory neuropathy
after Hereditary motor and sensory neuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hereditary motor and sensory neuropathy

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Endpoint not on priority list, no data to show.