Other headache syndromes

G6_HEADACHE

acute chest syndrome: A vaso-occlusive crisis of the pulmonary vasculature occurring in patients with sickle cell disease. It is characterized by the presence of a new radiodensity on a chest radiograph accompanied by fever, cough, sputum production, dyspnea, or hypoxia.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G44

Hospital discharge: ICD-8 34601

Cause of death: ICD-10 G44

Cause of death: ICD-8 34601

2 out of 7 registries used, show all original rules.

16493

Check minimum number of events None

16493

Include endpoints

G6_CLUSTHEADACHE_WIDE

16557

Remove individuals based on genotype QC

15851

G6_HEADACHE

Control definitions

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G40-G47

Name in latin Alia syndromata cephalalgica

NAME	G6_HEADACHE
CONTROL_EXCLUDE	G6_EPIPAROX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	G6_CLUSTHEADACHE_WIDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G44
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	34601
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G44
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	34601
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Other headache syndromes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	15851	11658	4193
Unadjusted prevalence (%)	4.20	5.53	2.52
Mean age at first event (years)	48.44	47.14	52.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.60 [1.26, 2.04]	1.4e-4	760
15 years	0.01	1.15 [0.92, 1.45]	2.3e-1	390
5 years	0.00	1.69 [1.34, 2.12]	7.1e-6	162
1 year	0.00	3.54 [2.61, 4.79]	2.9e-16	62

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_HEADACHE – Other headache syndromes
GWS hits: 4

Survival analyses between endpoints

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Plot

before Other headache syndromes
after Other headache syndromes

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other headache syndromes

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

R7

R6

R5

R4

R3