Guillain-Barre syndrome

G6_GUILBAR

Guillain-Barre syndrome: Guillain-BarrC) syndrome (GBS) is the term used to describe a spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS; see these terms) and some other regional variants.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G61.0
Hospital discharge: ICD-9 3570
Hospital discharge: ICD-8 35401
Cause of death: ICD-10 G61.0
Cause of death: ICD-9 3570
Cause of death: ICD-8 35401

2 out of 7 registries used, show all original rules.

432

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Check minimum number of events None

432

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Include endpoints None

432

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Remove individuals based on genotype QC

415

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G6_GUILBAR

Control definitions

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G61
Name in latin Syndroma Guillain-Barré

Summary Statistics

Key figures

All Female Male
Number of individuals 415 191 224
Unadjusted prevalence (%) 0.11 0.09 0.13
Mean age at first event (years) 48.91 45.41 51.89

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.19 [2.45, 7.16] 1.7e-7 50
15 years 0.01 2.27 [1.34, 3.86] 2.3e-3 24
5 years 0.00 3.07 [1.60, 5.88] 7.3e-4 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_GUILBAR – Guillain-Barre syndrome
GWS hits:

Survival analyses between endpoints

Plot

before Guillain-Barre syndrome
after Guillain-Barre syndrome

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Guillain-Barre syndrome

Endpoint not on priority list, no data to show.