Alcohol induced polyneuropathy

G6_ALCOPOLY

alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G62.1
Hospital discharge: ICD-9 3575A
Cause of death: ICD-10 G62.1
Cause of death: ICD-9 3575A

2 out of 7 registries used, show all original rules.

256

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Check minimum number of events None

256

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Include endpoints None

256

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Remove individuals based on genotype QC

249

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G6_ALCOPOLY

Control definitions

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G62
Name in latin Polyneuropathia alcoholica

Summary Statistics

Key figures

All Female Male
Number of individuals 249 45 204
Unadjusted prevalence (%) 0.07 0.02 0.12
Mean age at first event (years) 57.84 52.48 59.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_ALCOPOLY – Alcohol induced polyneuropathy
GWS hits:

Survival analyses between endpoints

Plot

before Alcohol induced polyneuropathy
after Alcohol induced polyneuropathy

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Drugs most likely to be purchased after Alcohol induced polyneuropathy

Endpoint not on priority list, no data to show.