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Schizophrenia

DOID EFO MESH SNOMED PheWeb

F5_SCHZPHR

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F20
Hospital discharge: ICD-9 295
Hospital discharge: ICD-8 295
Hospital discharge: excluded ICD-9 2954|2957
Hospital discharge: excluded ICD-8 2957
Cause of death: ICD-10 F20
Cause of death: ICD-9 295
Cause of death: ICD-8 295
Cause of death: excluded ICD-9 2954|2957
Cause of death: excluded ICD-8 2957

2 out of 7 registries used, show all original rules.

6774

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Check minimum number of events None

6774

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Include endpoints None

6774

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Remove individuals based on genotype QC

6515

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F5_SCHZPHR

Control definitions

Control exclude F5_SCHIZO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Summary Statistics

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Key figures

All Female Male
Number of individuals 6515 2911 3604
Unadjusted prevalence (%) 1.73 1.38 2.17
Mean age at first event (years) 32.42 33.53 31.52

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.53 [1.95, 3.27] 2.8e-12 564
15 years 0.01 1.64 [1.28, 2.10] 9.4e-5 198
5 years 0.00 2.53 [1.92, 3.33] 4.0e-11 78
1 year 0.00 4.29 [2.77, 6.65] 7.7e-11 25

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_SCHZPHR – Schizophrenia
GWS hits: 1

Survival analyses between endpoints

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Plot

before Schizophrenia
after Schizophrenia

loading spinner Loading survival analyses plot