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Profound mental retardation

DOID EFO MESH PheWeb

F5_PRORET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F73
Hospital discharge: ICD-9 3182
Hospital discharge: ICD-8 314
Cause of death: ICD-10 F73
Cause of death: ICD-9 3182
Cause of death: ICD-8 314

2 out of 7 registries used, show all original rules.

29

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Check minimum number of events None

29

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Include endpoints None

29

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Remove individuals based on genotype QC

29

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F5_PRORET

Control definitions

Control exclude F5_MENTRET

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F70-F79
Name in latin Retardatio mentalis profunda

Summary Statistics

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Key figures

All Female Male
Number of individuals 29 16 13
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 27.95 34.44 19.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_PRORET – Profound mental retardation
GWS hits:

Survival analyses between endpoints

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Not a core endpoint, no data to show.

Drugs most likely to be purchased after Profound mental retardation

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Endpoint not on priority list, no data to show.