Manic episode

F5_MANIA

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F30

Cause of death: ICD-10 F30

2 out of 7 registries used, show all original rules.

990

Check minimum number of events None

990

Include endpoints None

990

Remove individuals based on genotype QC

934

F5_MANIA

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F30-F39

Name in latin Mania

NAME	F5_MANIA
CONTROL_EXCLUDE	F5_MOOD
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F30
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F30
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Manic episode based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	934	513	421
Unadjusted prevalence (%)	0.25	0.24	0.25
Mean age at first event (years)	44.73	43.27	46.52

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	5.52 [3.43, 8.90]	2.1e-12	81
15 years	0.02	2.63 [1.56, 4.42]	2.8e-4	35
5 years	0.00	3.75 [2.18, 6.44]	1.6e-6	22
1 year	0.00	9.50 [4.33, 20.86]	2.0e-8	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_MANIA – Manic episode
GWS hits:

Survival analyses between endpoints

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Plot

before Manic episode
after Manic episode

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Manic episode

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

R7

R6

R5

R4

R3