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Bipolar affective disorders

DOID EFO MESH SNOMED PheWeb

F5_BIPO

bipolar disorder: A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 F31
Hospital discharge: ICD-9 296[2-7]
Hospital discharge: ICD-8 296
Hospital discharge: excluded ICD-8 2960|29699
Cause of death: ICD-10 F31
Cause of death: ICD-9 296[2-7]
Cause of death: ICD-8 296
Cause of death: excluded ICD-8 2960|29699

2 out of 7 registries used, show all original rules.

7271

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Check minimum number of events None

7271

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Include endpoints None

7271

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Remove individuals based on genotype QC

7006

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F5_BIPO

Control definitions

Control exclude F5_MOOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F30-F39
Name in latin Perturbatio affectiva bipolaris

Summary Statistics

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Key figures

All Female Male
Number of individuals 7006 4438 2568
Unadjusted prevalence (%) 1.86 2.11 1.54
Mean age at first event (years) 39.61 37.94 42.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.52 [2.64, 4.70] 1.2e-17 373
15 years 0.02 2.80 [2.21, 3.56] 2.6e-17 188
5 years 0.00 3.42 [2.56, 4.57] 1.1e-16 67
1 year 0.00 7.18 [4.66, 11.06] 4.2e-19 25

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_BIPO – Bipolar affective disorders
GWS hits:

Survival analyses between endpoints

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Plot

before Bipolar affective disorders
after Bipolar affective disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Bipolar affective disorders

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