Thyrotoxicosis with toxic multinodular goitre

DOID EFO MESH SNOMED PheWeb

E4_THYTOXGOITMULT

Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E05.2

Hospital discharge: ICD-9 2422

Hospital discharge: ICD-8 2421

Cause of death: ICD-10 E05.2

Cause of death: ICD-9 2422

Cause of death: ICD-8 2421

2 out of 7 registries used, show all original rules.

1640

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Check minimum number of events None

1640

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Include endpoints None

1640

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Remove individuals based on genotype QC

1600

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E4_THYTOXGOITMULT

Control definitions

Control exclude THYROTOXICOSIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E05

Name in latin Thyreotoxicosis cum struma multinodulari

NAME	E4_THYTOXGOITMULT
CONTROL_EXCLUDE	THYROTOXICOSIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E052
HD_ICD_9	2422
HD_ICD_8	2421
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E052
COD_ICD_9	2422
COD_ICD_8	2421
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Thyrotoxicosis with toxic multinodular goitre based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1600	1289	311
Unadjusted prevalence (%)	0.42	0.61	0.19
Mean age at first event (years)	57.93	56.68	63.13

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.71 [1.10, 2.66]	1.7e-2	170
15 years	0.01	0.95 [0.65, 1.38]	7.8e-1	64
5 years	0.00	1.87 [1.29, 2.71]	9.8e-4	41
1 year	0.00	3.87 [2.26, 6.65]	9.1e-7	17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 16

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with toxic multinodular goitre
after Thyrotoxicosis with toxic multinodular goitre

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Table

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Drugs most likely to be purchased after Thyrotoxicosis with toxic multinodular goitre

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Endpoint not on priority list, no data to show.