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Kwashiorkor

DOID EFO MESH SNOMED PheWeb

E4_KWASHIORKOR

kwashiorkor: A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning 'displaced child'. Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E40
Hospital discharge: ICD-9 260
Hospital discharge: ICD-8 268
Cause of death: ICD-10 E40
Cause of death: ICD-9 260
Cause of death: ICD-8 268

2 out of 7 registries used, show all original rules.

37

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Check minimum number of events None

37

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Include endpoints None

37

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Remove individuals based on genotype QC

37

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E4_KWASHIORKOR

Control definitions

Control exclude E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E40-E46
Name in latin Malnutritio gravis ex deficientia proteinica

Summary Statistics

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Key figures

All Female Male
Number of individuals 37 17 20
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 40.29 29.35 49.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_KWASHIORKOR – Kwashiorkor
GWS hits:

Survival analyses between endpoints

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Plot

before Kwashiorkor
after Kwashiorkor

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Drugs most likely to be purchased after Kwashiorkor

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Endpoint not on priority list, no data to show.