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Type 1 diabetes with renal complications

MESH PheWeb

E4_DM1REN

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.2+, E10.2+N08.39
Hospital discharge: ICD-9 2503B
Cause of death: ICD-10 E10.2+, E10.2+N08.39
Cause of death: ICD-9 2503B

2 out of 7 registries used, show all original rules.

1625

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Check minimum number of events None

1625

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Include endpoints None

1625

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Remove individuals based on genotype QC

1579

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E4_DM1REN

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1579 688 891
Unadjusted prevalence (%) 0.42 0.33 0.54
Mean age at first event (years) 42.64 38.71 45.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.18 13.35 [8.24, 21.63] 6.5e-26 316
15 years 0.04 6.48 [3.78, 11.09] 1.0e-11 130
5 years 0.02 13.75 [9.36, 20.19] 8.3e-41 104
1 year 0.00 19.29 [12.22, 30.46] 5.6e-37 31

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1REN – Type 1 diabetes with renal complications
GWS hits: 6

Survival analyses between endpoints

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Plot

before Type 1 diabetes with renal complications
after Type 1 diabetes with renal complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with renal complications

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Endpoint not on priority list, no data to show.