Type 1 diabetes with peripheral circulatory complications

E4_DM1PERIPH

diabetic angiopathy: VASCULAR DISEASES that are associated with DIABETES MELLITUS.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.5
Hospital discharge: ICD-9 2506B
Cause of death: ICD-10 E10.5
Cause of death: ICD-9 2506B

2 out of 7 registries used, show all original rules.

680

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Check minimum number of events None

680

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Include endpoints None

680

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Remove individuals based on genotype QC

669

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E4_DM1PERIPH

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10

Summary Statistics

Key figures

All Female Male
Number of individuals 669 249 420
Unadjusted prevalence (%) 0.18 0.12 0.25
Mean age at first event (years) 50.31 46.87 52.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.92 [1.19, 12.96] 2.5e-2 209
15 years 0.02 3.21 [1.26, 8.22] 1.5e-2 93
5 years 0.01 7.12 [3.61, 14.05] 1.6e-8 67
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DM1PERIPH – Type 1 diabetes with peripheral circulatory complications
GWS hits: 2

Survival analyses between endpoints

Plot

before Type 1 diabetes with peripheral circulatory complications
after Type 1 diabetes with peripheral circulatory complications

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Drugs most likely to be purchased after Type 1 diabetes with peripheral circulatory complications

Endpoint not on priority list, no data to show.