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Type 1 diabetes with ophthalmic complications

DOID EFO MESH SNOMED PheWeb

E4_DM1OPTH

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Hospital discharge: ICD-9 2504B
Cause of death: ICD-10 E10.3+, E10.3+H28.0, E10.3+H36.09
Cause of death: ICD-9 2504B

2 out of 7 registries used, show all original rules.

5328

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Check minimum number of events None

5328

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Include endpoints None

5328

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Remove individuals based on genotype QC

5202

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E4_DM1OPTH

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 5202 2693 2509
Unadjusted prevalence (%) 1.38 1.28 1.51
Mean age at first event (years) 38.36 36.88 39.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.37 [2.62, 7.29] 1.5e-8 460
15 years 0.02 3.19 [2.02, 5.06] 7.6e-7 229
5 years 0.01 4.56 [3.11, 6.69] 9.1e-15 89
1 year 0.00 6.94 [4.19, 11.51] 5.7e-14 24

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1OPTH – Type 1 diabetes with ophthalmic complications
GWS hits: 38

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ophthalmic complications
after Type 1 diabetes with ophthalmic complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with ophthalmic complications

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Endpoint not on priority list, no data to show.