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Type 1 diabetes with ketoacidosis

DOID EFO MESH SNOMED PheWeb

E4_DM1KETO

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.1
Hospital discharge: ICD-9 2501B
Cause of death: ICD-10 E10.1
Cause of death: ICD-9 2501B

2 out of 7 registries used, show all original rules.

2144

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Check minimum number of events None

2144

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Include endpoints None

2144

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Remove individuals based on genotype QC

2102

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E4_DM1KETO

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10

Summary Statistics

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Key figures

All Female Male
Number of individuals 2102 1069 1033
Unadjusted prevalence (%) 0.56 0.51 0.62
Mean age at first event (years) 25.97 24.85 27.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.25 19.34 [9.17, 40.80] 7.4e-15 211
15 years 0.05 8.19 [3.55, 18.88] 8.1e-7 81
5 years 0.02 14.44 [6.60, 31.58] 2.3e-11 49
1 year 0.01 61.28 [29.61, 126.80] 1.4e-28 39

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1KETO – Type 1 diabetes with ketoacidosis
GWS hits: 14

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ketoacidosis
after Type 1 diabetes with ketoacidosis

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Drugs most likely to be purchased after Type 1 diabetes with ketoacidosis

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Endpoint not on priority list, no data to show.