Diabetes, several complications

DM_SEVERAL_COMPLICATIONS

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.7, E10.8, E11.7, E11.8, E12.7, E12.8, E13.7, E13.8, E14.7, E14.8
Hospital discharge: excluded ICD-10 E12.7, E12.8
Cause of death: ICD-10 E10.7, E10.8, E11.7, E11.8, E12.7, E12.8, E13.7, E13.8, E14.7, E14.8

2 out of 7 registries used, show all original rules.

16881

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Check minimum number of events None

16881

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Include endpoints None

16881

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Remove individuals based on genotype QC

16320

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DM_SEVERAL_COMPLICATIONS

Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 16320 6271 10049
Unadjusted prevalence (%) 4.33 2.97 6.04
Mean age at first event (years) 62.99 61.03 64.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 7.45 [6.53, 8.49] <1e-100 4171
15 years 0.02 2.78 [2.46, 3.15] 1.5e-60 1231
5 years 0.01 5.96 [5.31, 6.68] <1e-100 1372
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DM_SEVERAL_COMPLICATIONS – Diabetes, several complications
GWS hits: 17

Survival analyses between endpoints

Plot

before Diabetes, several complications
after Diabetes, several complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetes, several complications

Endpoint not on priority list, no data to show.