Diabetic ketoacidosis


diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Hospital discharge: ICD-9 2500
Hospital discharge: excluded ICD-10 E12.1
Cause of death: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Cause of death: ICD-9 2500
Cause of death: excluded ICD-10 E12.1

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 7841 3513 4328
Unadjusted prevalence (%) 2.08 1.67 2.60
Mean age at first event (years) 35.93 32.34 38.85


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.71 [2.06, 3.58] 1.8e-12 1891
15 years 0.01 1.76 [1.46, 2.13] 5.3e-9 814
5 years 0.00 2.58 [2.23, 2.99] 2.8e-37 418
1 year 0.00 5.90 [4.89, 7.11] 2.7e-77 195

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: DM_KETOACIDOSIS – Diabetic ketoacidosis
GWS hits: 29

Survival analyses between endpoints


before Diabetic ketoacidosis
after Diabetic ketoacidosis

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Drugs most likely to be purchased after Diabetic ketoacidosis

Endpoint not on priority list, no data to show.