≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Diabetic ketoacidosis

DOID EFO MESH SNOMED PheWeb

DM_KETOACIDOSIS

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Hospital discharge: ICD-9 2500
Hospital discharge: excluded ICD-10 E12.1
Cause of death: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1
Cause of death: ICD-9 2500
Cause of death: excluded ICD-10 E12.1

2 out of 7 registries used, show all original rules.

8048

diagram downward connector

Check minimum number of events None

8048

diagram downward connector

Include endpoints None

8048

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

7841

diagram downward connector
DM_KETOACIDOSIS

Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 7841 3513 4328
Unadjusted prevalence (%) 2.08 1.67 2.60
Mean age at first event (years) 35.93 32.34 38.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.71 [2.06, 3.58] 1.8e-12 1891
15 years 0.01 1.76 [1.46, 2.13] 5.3e-9 814
5 years 0.00 2.58 [2.23, 2.99] 2.8e-37 418
1 year 0.00 5.90 [4.89, 7.11] 2.7e-77 195

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: DM_KETOACIDOSIS – Diabetic ketoacidosis
GWS hits: 29

Survival analyses between endpoints

↥

Plot

before Diabetic ketoacidosis
after Diabetic ketoacidosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic ketoacidosis

↥

Endpoint not on priority list, no data to show.