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Idiopathic thrombocytopenic purpura

DOID EFO MESH PheWeb

D3_ITP

autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D69.3
Hospital discharge: ICD-9 2873A
Hospital discharge: ICD-8 28710
Cause of death: ICD-10 D69.3
Cause of death: ICD-9 2873A
Cause of death: ICD-8 28710

2 out of 7 registries used, show all original rules.

839

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Check minimum number of events None

839

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Include endpoints None

839

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Remove individuals based on genotype QC

810

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D3_ITP

Control definitions

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura idiopathica thrombocytopenica

Similar endpoints

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List of similar endpoints to Idiopathic thrombocytopenic purpura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 810 427 383
Unadjusted prevalence (%) 0.21 0.20 0.23
Mean age at first event (years) 48.92 43.70 54.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.61 [3.19, 9.86] 2.1e-9 131
15 years 0.01 2.08 [1.20, 3.62] 9.6e-3 40
5 years 0.01 5.43 [3.55, 8.30] 5.2e-15 40
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits:

Survival analyses between endpoints

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Plot

before Idiopathic thrombocytopenic purpura
after Idiopathic thrombocytopenic purpura

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Drugs most likely to be purchased after Idiopathic thrombocytopenic purpura

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Endpoint not on priority list, no data to show.