Vitamin B12 deficiency anaemia

D3_ANAEMIA_B12_DEF

vitamin B12 deficiency: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D51
Hospital discharge: ICD-9 281[0-1]
Hospital discharge: ICD-8 281[0-1]
Cause of death: ICD-10 D51
Cause of death: ICD-9 281[0-1]
Cause of death: ICD-8 281[0-1]
KELA reimbursements: KELA codes 107

3 out of 7 registries used, show all original rules.

3469

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Check minimum number of events None

3469

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Include endpoints None

3469

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Remove individuals based on genotype QC

3351

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D3_ANAEMIA_B12_DEF

Control definitions

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D50-D53
Name in latin Anaemia ex deficientia vitamini B12

Summary Statistics

Key figures

All Female Male
Number of individuals 3351 1698 1653
Unadjusted prevalence (%) 0.89 0.81 0.99
Mean age at first event (years) 60.79 56.96 64.73

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.68 [1.16, 2.43] 5.7e-3 974
15 years 0.01 1.04 [0.78, 1.38] 7.8e-1 387
5 years 0.00 2.62 [2.14, 3.20] 5.1e-21 320
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_ANAEMIA_B12_DEF – Vitamin B12 deficiency anaemia
GWS hits: 12

Survival analyses between endpoints

Plot

before Vitamin B12 deficiency anaemia
after Vitamin B12 deficiency anaemia

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Drugs most likely to be purchased after Vitamin B12 deficiency anaemia

Endpoint not on priority list, no data to show.