Vitamin B12 deficiency anaemia

DOID EFO MESH SNOMED PheWeb

D3_ANAEMIA_B12_DEF

vitamin B12 deficiency: A disease characterized by low serum levels of vitamin B12, either inherited or acquired.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D51

Hospital discharge: ICD-9 281[0-1]

Hospital discharge: ICD-8 281[0-1]

Cause of death: ICD-10 D51

Cause of death: ICD-9 281[0-1]

Cause of death: ICD-8 281[0-1]

KELA reimbursements: KELA codes 107

3 out of 7 registries used, show all original rules.

3469

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Check minimum number of events None

3469

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Include endpoints None

3469

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Remove individuals based on genotype QC

3351

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D3_ANAEMIA_B12_DEF

Control definitions

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D50-D53

Name in latin Anaemia ex deficientia vitamini B12

NAME	D3_ANAEMIA_B12_DEF
CONTROL_EXCLUDE	D3_NUTRIANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D51
HD_ICD_9	281[0-1]
HD_ICD_8	281[0-1]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D51
COD_ICD_9	281[0-1]
COD_ICD_8	281[0-1]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	107
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Vitamin B12 deficiency anaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3351	1698	1653
Unadjusted prevalence (%)	0.89	0.81	0.99
Mean age at first event (years)	60.79	56.96	64.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.68 [1.16, 2.43]	5.7e-3	974
15 years	0.01	1.04 [0.78, 1.38]	7.8e-1	387
5 years	0.00	2.62 [2.14, 3.20]	5.1e-21	320
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ANAEMIA_B12_DEF – Vitamin B12 deficiency anaemia
GWS hits: 12

Survival analyses between endpoints

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Plot

before Vitamin B12 deficiency anaemia
after Vitamin B12 deficiency anaemia

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Table

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Drugs most likely to be purchased after Vitamin B12 deficiency anaemia

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Endpoint not on priority list, no data to show.