Allergic purpura

D3_ALLERGPURPURA

Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D69.0
Hospital discharge: ICD-9 2870
Hospital discharge: ICD-8 2870
Cause of death: ICD-10 D69.0
Cause of death: ICD-9 2870
Cause of death: ICD-8 2870

2 out of 7 registries used, show all original rules.

889

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Check minimum number of events None

889

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Include endpoints None

889

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Remove individuals based on genotype QC

856

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D3_ALLERGPURPURA

Control definitions

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura allergica

Similar endpoints

List of similar endpoints to Allergic purpura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 856 506 350
Unadjusted prevalence (%) 0.23 0.24 0.21
Mean age at first event (years) 39.05 36.25 43.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 9.04 [5.81, 14.06] 1.6e-22 101
15 years 0.02 3.23 [1.95, 5.36] 5.6e-6 32
5 years 0.01 6.71 [3.91, 11.51] 5.1e-12 29
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: 2

Survival analyses between endpoints

Plot

before Allergic purpura
after Allergic purpura

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Drugs most likely to be purchased after Allergic purpura

Endpoint not on priority list, no data to show.