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Allergic purpura

DOID EFO MESH SNOMED PheWeb

D3_ALLERGPURPURA

Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D69.0
Hospital discharge: ICD-9 2870
Hospital discharge: ICD-8 2870
Cause of death: ICD-10 D69.0
Cause of death: ICD-9 2870
Cause of death: ICD-8 2870

2 out of 7 registries used, show all original rules.

889

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Check minimum number of events None

889

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Include endpoints None

889

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Remove individuals based on genotype QC

856

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D3_ALLERGPURPURA

Control definitions

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D69
Name in latin Purpura allergica

Similar endpoints

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List of similar endpoints to Allergic purpura based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 856 506 350
Unadjusted prevalence (%) 0.23 0.24 0.21
Mean age at first event (years) 39.05 36.25 43.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.13 9.04 [5.81, 14.06] 1.6e-22 101
15 years 0.02 3.23 [1.95, 5.36] 5.6e-6 32
5 years 0.01 6.71 [3.91, 11.51] 5.1e-12 29
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: 2

Survival analyses between endpoints

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Plot

before Allergic purpura
after Allergic purpura

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Drugs most likely to be purchased after Allergic purpura

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Endpoint not on priority list, no data to show.