Chronic myeloproliferative disease

CHRONMYELOPRO

chronic myeloproliferative disorder: A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 D47.1
Cause of death: ICD-10 D47.1

2 out of 7 registries used, show all original rules.

341

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Check minimum number of events None

341

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Include endpoints None

341

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Remove individuals based on genotype QC

328

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CHRONMYELOPRO

Control definitions

Control exclude MYELOPROF

Extra metadata

First used in FinnGen datafreeze DF2, additional

Summary Statistics

Key figures

All Female Male
Number of individuals 328 148 180
Unadjusted prevalence (%) 0.09 0.07 0.11
Mean age at first event (years) 63.55 61.98 64.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CHRONMYELOPRO – Chronic myeloproliferative disease
GWS hits: 2

Survival analyses between endpoints

Plot

before Chronic myeloproliferative disease
after Chronic myeloproliferative disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chronic myeloproliferative disease

Endpoint not on priority list, no data to show.