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Other and unspecified types of non-Hodgkin lymphoma

DOID EFO MESH PheWeb

CD2_NONHODGKIN_NAS

non-Hodgkins lymphoma: Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C85
Hospital discharge: ICD-9 200[8-9]
Cause of death: ICD-10 C85
Cause of death: ICD-9 200[8-9]

2 out of 7 registries used, show all original rules.

1126

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Check minimum number of events None

1126

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Include endpoints None

1126

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Remove individuals based on genotype QC

1088

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CD2_NONHODGKIN_NAS

Control definitions

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8
Parent code in ICD-10 C81-C96
Name in latin Typi alii et non specificati lymphomatis non-Hodgkin

Similar endpoints

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List of similar endpoints to Other and unspecified types of non-Hodgkin lymphoma based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1088 459 629
Unadjusted prevalence (%) 0.29 0.22 0.38
Mean age at first event (years) 61.96 60.08 63.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.92 [1.39, 6.14] 4.8e-3 300
15 years 0.01 1.03 [0.56, 1.90] 9.3e-1 66
5 years 0.00 3.97 [2.54, 6.21] 1.4e-9 74
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_NONHODGKIN_NAS – Other and unspecified types of non-Hodgkin lymphoma
GWS hits:

Survival analyses between endpoints

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Plot

before Other and unspecified types of non-Hodgkin lymphoma
after Other and unspecified types of non-Hodgkin lymphoma

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Drugs most likely to be purchased after Other and unspecified types of non-Hodgkin lymphoma

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