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Non-follicular lymphoma

DOID EFO MESH SNOMED PheWeb

CD2_NONFOLLICULAR_LYMPHOMA

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C83
Hospital discharge: ICD-9 200
Hospital discharge: excluded ICD-9 200A
Cause of death: ICD-10 C83
Cause of death: ICD-9 200
Cause of death: excluded ICD-9 200A

2 out of 7 registries used, show all original rules.

2693

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Check minimum number of events None

2693

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Include endpoints None

2693

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Remove individuals based on genotype QC

2602

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CD2_NONFOLLICULAR_LYMPHOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin diffusum

Similar endpoints

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List of similar endpoints to Non-follicular lymphoma based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 2602 1043 1559
Unadjusted prevalence (%) 0.69 0.49 0.94
Mean age at first event (years) 63.36 61.45 64.64

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.32 [2.13, 8.76] 5.0e-5 606
15 years 0.01 1.16 [0.51, 2.62] 7.2e-1 143
5 years 0.00 4.40 [2.61, 7.41] 2.6e-8 187
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CD2_NONFOLLICULAR_LYMPHOMA – Non-follicular lymphoma
GWS hits: 1

Survival analyses between endpoints

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Plot

before Non-follicular lymphoma
after Non-follicular lymphoma

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Drugs most likely to be purchased after Non-follicular lymphoma

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Endpoint not on priority list, no data to show.