≡ Risteys
R9

Documentation Changelog GitHub Contact & Feedback

Follicular lymphoma

DOID EFO MESH SNOMED PheWeb

CD2_FOLLICULAR_LYMPHOMA

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

↥
FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C82
Hospital discharge: ICD-9 2000A
Cause of death: ICD-10 C82
Cause of death: ICD-9 2000A

2 out of 7 registries used, show all original rules.

1116

diagram downward connector

Check minimum number of events None

1116

diagram downward connector

Include endpoints None

1116

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

1081

diagram downward connector
CD2_FOLLICULAR_LYMPHOMA

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin nodulare (folliculare)

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 1081 545 536
Unadjusted prevalence (%) 0.29 0.26 0.32
Mean age at first event (years) 62.00 60.80 63.21

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.45 [3.43, 8.65] 6.8e-13 165
15 years 0.01 2.23 [1.40, 3.57] 7.6e-4 55
5 years 0.01 5.88 [3.71, 9.32] 4.5e-14 61
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: CD2_FOLLICULAR_LYMPHOMA – Follicular lymphoma
GWS hits: 1

Survival analyses between endpoints

↥

Plot

before Follicular lymphoma
after Follicular lymphoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Follicular lymphoma

↥

Endpoint not on priority list, no data to show.