Follicular lymphoma


neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 C82
Hospital discharge: ICD-9 2000A
Cause of death: ICD-10 C82
Cause of death: ICD-9 2000A

2 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin nodulare (folliculare)

Summary Statistics

Key figures

All Female Male
Number of individuals 1081 545 536
Unadjusted prevalence (%) 0.29 0.26 0.32
Mean age at first event (years) 62.00 60.80 63.21


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.45 [3.43, 8.65] 6.8e-13 165
15 years 0.01 2.23 [1.40, 3.57] 7.6e-4 55
5 years 0.01 5.88 [3.71, 9.32] 4.5e-14 61
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: CD2_FOLLICULAR_LYMPHOMA – Follicular lymphoma
GWS hits: 1

Survival analyses between endpoints


before Follicular lymphoma
after Follicular lymphoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Follicular lymphoma

Endpoint not on priority list, no data to show.