Certain zoonotic bacterial diseases

AB1_ZOONOTIC_BACTERIAL

Yersinia pestis infectious disease: Plague is a severe bacterial infection caused by the gram-negative bacterium Yersinia pestis.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A20-A28

Hospital discharge: ICD-9 02[0-7]|B783A

Hospital discharge: ICD-8 02[0-7]

Cause of death: ICD-10 A20-A28

Cause of death: ICD-9 02[0-7]|B783A

Cause of death: ICD-8 02[0-7]

2 out of 7 registries used, show all original rules.

464

Check minimum number of events None

464

Include endpoints

AB1_PLAGUE

AB1_TULARAEMIA

AB1_ANTHRAX

AB1_BRUCELLOSIS

AB1_GHANDERS_N_MELIOIDOSIS

AB1_RATBITEFEVERS

AB1_ERYSIPLEOID

AB1_LEPTOSPIROSIS

AB1_OTHER_ZOONOTIC

464

Remove individuals based on genotype QC

450

AB1_ZOONOTIC_BACTERIAL

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	AB1_ZOONOTIC_BACTERIAL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	AB1_PLAGUE\|AB1_TULARAEMIA\|AB1_ANTHRAX\|AB1_BRUCELLOSIS\|AB1_GHANDERS_N_MELIOIDOSIS\|AB1_RATBITEFEVERS\|AB1_ERYSIPLEOID\|AB1_LEPTOSPIROSIS\|AB1_OTHER_ZOONOTIC
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A2[0-8]
HD_ICD_9	02[0-7]\|B783A
HD_ICD_8	02[0-7]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A2[0-8]
COD_ICD_9	02[0-7]\|B783A
COD_ICD_8	02[0-7]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Similar endpoints

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List of similar endpoints to Certain zoonotic bacterial diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	450	223	227
Unadjusted prevalence (%)	0.12	0.11	0.14
Mean age at first event (years)	48.37	44.88	51.81

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.31 [1.25, 8.80]	1.6e-2	57
15 years	0.01	1.18 [0.40, 3.51]	7.6e-1	17
5 years	0.00	3.62 [1.61, 8.12]	1.9e-3	15
1 year	0.00	15.53 [7.43, 32.47]	3.1e-13	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_ZOONOTIC_BACTERIAL – Certain zoonotic bacterial diseases
GWS hits:

Survival analyses between endpoints

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Plot

before Certain zoonotic bacterial diseases
after Certain zoonotic bacterial diseases

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Table

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Drugs most likely to be purchased after Certain zoonotic bacterial diseases

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Endpoint not on priority list, no data to show.

≡ Risteys

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