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Infections with a predominantly sexual mode of transmission

DOID EFO MESH SNOMED PheWeb

AB1_SEXUAL_TRANSMISSION

tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 A50-A64
Hospital discharge: ICD-9 09[0-9]|0541|131|0781C
Hospital discharge: ICD-8 09[0-9]|131
Cause of death: ICD-10 A50-A64
Cause of death: ICD-9 09[0-9]|0541|131|0781C
Cause of death: ICD-8 09[0-9]|131

2 out of 7 registries used, show all original rules.

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Check minimum number of events None

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Include endpoints

11444

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Remove individuals based on genotype QC

10937

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AB1_SEXUAL_TRANSMISSION

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Infections with a predominantly sexual mode of transmission based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 10937 8087 2850
Unadjusted prevalence (%) 2.90 3.84 1.71
Mean age at first event (years) 32.66 31.27 36.60

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.86 [0.99, 3.48] 5.2e-2 337
15 years 0.01 0.94 [0.40, 2.21] 8.8e-1 120
5 years 0.00 2.22 [1.08, 4.55] 3.0e-2 65
1 year 0.00 3.79 [1.77, 8.09] 5.9e-4 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission
GWS hits:

Survival analyses between endpoints

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Plot

before Infections with a predominantly sexual mode of transmission
after Infections with a predominantly sexual mode of transmission

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Drugs most likely to be purchased after Infections with a predominantly sexual mode of transmission

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Endpoint not on priority list, no data to show.